Your adverts interfere with my reading of my email. They flash. They change colors, they move. I'm not going to click on them, so why bother advertising to me?
Adverts interfere with email. I'm not shutting down my ad-block.
Your "helpful" interference is... interference. Those popups that ask me if I want to unsub from emails are the worst I've ever seen, they don't work automatically, I have to do it manually. Get it out of there. And get rid of adverts in email!